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兼职教授

李盛本,2008年于中国科学院遗传与发育生物学研究所获得博士学位,2007-2015年在美国加州大学河滨分校进行博士后研究。先后入选农业部“全国农业科研杰出人才”,科技部“中青年科技创新领军人才”和“国家万人计划领军人才”,2018年获得广东省“五一劳动奖章”, 2015年起担任中国农业科学院学术委员会委员。

1.研究领域
1)植物基因表达的转录后调控机制研究。鉴定植物小RNA途径的新原件,探索小RNA生物合成及调控机制;2)农作物小分子RNA生物学功能研究。利用功能基因组学技术对农作物小RNA进行高通量系统研究;3)玉米生长发育和重要农艺性状形成的分子机制研究。通过分子遗传学、基因组学和表型组学对影响玉米发育的关键基因进行克隆和功能研究。

2.学术成果
在植物小RNA生物合成及作用机制方面进行了长期的研究,发现了内质网在小RNA对靶基因进行翻译抑制过程中的作用,解析了植物内质网上小RNA的分布模式和对次级小RNA生物合成的重要作用。

3.发表文章
1.Shengben Li, Brandon Le, Xuan Ma, Shaofang Li, Chenjiang You,Yu Yu, Bailong Zhang, Lin Liu, Lei Gao, Ting Shi, Yonghui Zhao,Beixin Mo, Xiaofeng Cao, Xuemei Chen. (2016) Biogenesis of phased siRNAs on membrane-bound polysomes in Arabidopsis. eLife 5:e22750.
2.Shengben Li, Lin Liu, Xiaohong Zhuang, Yu Yu, Xigang Liu, Xia Cui, Lijuan Ji, Zhiqiang Pan, Xiaofeng Cao, Beixin Mo, Fuchun Zhang, Natasha Raikhen, Liwen Jiang, and Xuemei Chen. (2013). MicroRNAs Inhibit the Translation of Target mRNAs on the Endoplasmic Reticulum in Arabidopsis. Cell 153, 562-574.
3.Shengben Li, Qian Qian, Zhiming Fu, Dali Zeng, Xianbing Meng, Junko Kyozuka, Masahiko Maekawa, Xudong Zhu, Jian Zhang, Jiayang Li and Yonghong Wang (2009). Short panicle1 encodes a putative PTR family transporter and determines rice panicle size. The Plant Journal 58, 592-605.
4.Yihua Zhou*, Shengbe Li*, Qian Qian, Dali Zeng, Mu Zhang, Longbiao Guo, Xinfang Liu, Baocai Zhang, Lingwei Deng, Guanzheng Luo, Xiujie Wang, and Jiayang Li (2009). BC10, a DUF266- containing and Golgi-located type II membrane protein, is required for cell-wall biosynthesis in rice (Oryza sativa L.). The Plant Journal 57, 446-462. (*共同第一作者)
5.Shaofang Li, Lee E. Vandivier, Bin Tu, Lei Gao, So Youn Won, Shengben Li, Binglian Zheng, Brian D. Gregory, and Xuemei Chen (2015). Detection of Pol IV/RDR2-dependent transcripts at the genomic scale in Arabidopsis reveals features and regulation of siRNA biogenesis.Genome Research 25(2):235
6.Qian Du, Utku Avci, Shengben Li, Lina Gallego-Giraldo, Sivakumar Pattathil, Liying Qi, Michael G. Hahn andHuanzhong Wang (2015). Activation of miR165b represses AtHB15 expression and induces pith secondary wall development in Arabidopsis. The Plant Journal 83(3):388-400
7.Bin Tu, Li Liu,Chi Xu, Jixian Zhai, Shengben Li, Miguel A. Lopez, Yuanyuan Zhao, Yu Yu, Vanitharani Ramachandran, Guodong Ren, Bin Yu, Shigui Li, Blake C. Meyers, Beixin Mo, Xuemei Chen(2015).Distinct and cooperative activities of HESO1 and URT1 nucleotidyl transferases in 2 microRNA turnover in Arabidopsis. PLoS Genetics 11(4):e1005119
8.Shaofang Li, Lee E. Vandivier, Bin Tu, Lei Gao, So Youn Won, Shengben Li, Binglian Zheng, Brian D. Gregory, and Xuemei Chen. (2015) Detection of Pol IV/RDR2-dependent transcripts at the genomic scale in Arabidopsis reveals features and regulation of siRNA biogenesis. Genome Research 25(2):235-45.
9.James Wong, Lei Gao, Yang Yang, Jixian Zhai, Siwaret Arikit, Yu Yu, Shuyi Duan, Vicky Chan, Qin Xiong, Jun Yan, Shengben Li, Renyi Liu, Yuanchao Wang, Guiliang Tang, Blake C. Meyers, Xuemei Chen, Wenbo Ma (2014). Roles of Small RNAs in Soybean Defense against Phytophthora sojae Infection. The Plant Journal 79(6):928-40.
10.Thanh Theresa Dinh, Michael O'Leary, So Youn Won, Shengben Li, Lorena Arroyo, Xigang Liu, Andrew Defries, Binglian Zheng, Sean R Cutler, and Xuemei Chen (2013). Generation of a luciferasebased reporter for CHH and CG DNA methylation in Arabidopsis thaliana. Silence 4, 1.
11.Tzuu-fen Lee, Sai Guna Gurazada, Jixian Zhai, Shengben Li, Stacey A. Simon, Marjori Matzke, Xuemei Chen and Blake C. Meyers (2012). RNA polymerase V-dependent small RNAs in Arabidopsis originate from small, intergenic loci including most SINE repeats. Epigenetics 7, 781-795.
12.Xurong Tang, Shaomin Bian, Mingjuan Tang, Qing Lu, Shengben Li, Xigang Liu, Gang Tian, Vi Nguyen, Edward W. T.Tsang, Aiming Wang, Steven J. Rothstein, Xuemei Chen and Yuhai Cui (2012). MicroRNA-mediated repression of the seed maturation program during vegetative development in Arabidopsis. PLoS Genetics 8, e1003091.
13.So Yun Won, Shengben Li, Binglian Zheng, Yuanyuan Zhao, Dongming Li, Xin Zhao, Huila Yi, Lei Gao, Thanh Theresa Dinh, and Xuemei Chen (2012). Development of a luciferase-based reporter of transcriptional gene silencing that enables bidirectional mutant screening in Arabidopsis thaliana. Silence 3, 6.
14.Bin Yu, Liu Bi, Jixian Zhai, Manu Agarwal, Shengben Li, Qingfa Wu, Shou-wei Ding, Blake C. Meyers, Herve Vaucheret, and Xuemei Chen (2010). siRNAs compete with miRNAs for methylation by HEN1 in Arabidopsis. Nucleic Acids Research 38, 5844-5850. 14. Binglian Zheng, Zhengming Wang, Shengben Li, Bin Yu, Jinyuan Liu, and Xuemei Chen (2009). Intergenic transcription by RNA polymerase II coordinates Pol IV and Pol V in siRNA-directed transcriptional gene silencing in Arabidopsis. Genes & Development 23, 2850-2860.

熊国胜 教授, 博士生导师,中国农业生物技术学会植物表型组学专业委员会委员。在2006年于中国科学院遗传与发育生物学研究所获得博士学位。2006-2009年期间先后在美国佐治亚医学院和南加州大学医学院从事博士后研究。2009年回国后在中国科学院遗传与发育生物学研究所工作,先后任助理研究员和副研究员。2014年入选中国农业科学院“青年英才”计划,任中国农科院深圳农业基因组研究所研究员。2018年加入南京农业大学作物表型组学交叉中心。主要研究领域为水稻功能基因组学,重点研究水稻重要农艺性状的遗传调控网络与植物激素信号转导的分子机制。在水稻重要农艺性状形成的分子基础等方面进行了比较系统的研究并取得了重要进展,作为主要作者的研究论文在国家著名学术期刊 Nature、Nature Genetics、Plant Cell 和 Molecular Plant上发表。
代表性论文
1.Wang Y, Xiong G, Hu J, Jiang L, Yu H, Xu J, Fang Y, Zeng L, Xu E, Xu J, Ye W, Meng X, Liu R, Chen H, Jing Y, Wang Y, Zhu X, Li J, Qian Q. (2015) Copy number variation at the GL7 locus contributes o grain size diversity in rice. Nature Genetics. 47, 944-948. (共同第一作者)
2.Jiang L, Liu X, Xiong G, Liu H, Chen F, Wang L, Meng X, Liu G, Yu H, Yuan Y, Yi W, Zhao L, Ma H, He Y, Wu Z, Melcher K, Qian Q, Xu H, Wang Y and Li J (2013) DWARF 53 acts as a repressor of strigolactone signaling in rice. Nature 504: 401-405. (共同第一作者)
3.Lu Z, Yu H, Xiong G, Wang J, Jiao Y, Guifu Liu G, Jing Y, Meng X, Hu X, Qian Q, Fu X, Wang Y and Li J (2013) Genome-wide binding analysis of the transcription activator IPA1 reveals a complex network regulating rice plant architecture. Plant Cell 25: 3743-3759. (共同第一作者)
4.Chen , Xiong G, Cui X, Yan Y, Xu T, Qian Q, Xue Y, Li J and Wang Y (2013) OsGRAS19 may be a novel component involved in the brassinosteroid signaling pathway in rice. Molecular Plant 6: 988-991. (共同第一作者)
5.Li J, Yuan Y, Lu Z, Yang L, Gao R, Lu J, Li J and Xiong G (2012) Glabrous Rice 1, encoding a homeodomain protein, regulates trichome development in rice. Rice 5: 32.
6.Xiong G, Hu XM, Jiao YQ, Yu YC, Chu CC, Li JY, Qian Q, Wang YH. (2006) LEAFY HEAD2, which encodes a putative RNA-binding protein, regulates shoot development of rice. Cell Research. 16: 267-276.
7.Li X, Qian Q, Fu Z, Wang Y, Xiong G, Zeng D, Wang X, Liu X, Teng S, Hiroshi F, Yuan M, Luo D, Han B, Li J. (2003) Control of tillering in rice (Oryza sativa L.). Nature. 422: 618-621.

 

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